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  • Current: LC-MS/MS - Liquid Chromatography Mass Spectrometry

LC-MS/MS

 

EXPERTISE IN LC-MS AND HYBRID LC-MS BIOANALYSIS

Our specialized LC-MS and hybrid LC-MS bioanalytical solutions deliver exceptional precision and sensitivity across preclinical and clinical drug development phases. Leveraging advanced instrumentation, we produce high-quality, regulatory-compliant PK/TK data and biomarker quantification, enabling rapid, informed decisions at every stage.

KEY LC-MS/MS APPLICATIONS

With decades of experience in LC-MS/MS, we provide high-sensitivity bioanalytical solutions for small molecules, peptides, proteins, monoclonal antibodies, antibody-drug conjugates (ADCs), and oligonucleotides. Our advanced hybrid LC-MS workflows further enhance large molecule bioanalysis, delivering precise and reliable data across all preclinical and clinical development phases.

Our Offering

We deliver comprehensive bioanalytical services to support drug development from early discovery through clinical phases. Our expertise spans small and large molecule quantification, biomarker validation, and regulatory-compliant studies. With advanced technology platforms and experienced scientific teams, we generate high-quality data that drives confident decision-making.

Quantification of Small and Large Molecules

  • We accurately quantify small molecules, peptides, proteins, monoclonal antibodies, antibody-drug conjugates (ADCs), and oligonucleotides.

Biomarker Discovery and Validation

  • We deliver high-sensitivity detection and quantification of biomarkers to accelerate early-phase development and translational research.

Immunoaffinity and Hybrid LC-MS Workflows

  • We enhance sensitivity and selectivity by combining immunoaffinity enrichment with LC-MS workflows.

Pharmacokinetic (PK) and Pharmacodynamic (PD) Support

  • We provide precise bioanalytical data to support PK/PD studies and evaluate drug absorption, distribution, metabolism, and elimination (ADME).

Microsampling and Low-Volume Analysis

  • We use microsampling technologies to enable low-volume blood collection in both preclinical and clinical settings.

Bioavailability and Bioequivalence Studies

  • We generate critical data to support formulation development and regulatory submissions.

GLP and non-GLP Studies

  • We support GLP and non-GLP studies with compliant, high-quality data across all phases of drug development.

From early-phase candidate assessment to regulatory submission, our tailored bioanalytical solutions provide the precision and reliability required to support your drug development program.

Get expert answers about your lc-ms/ms projects.

WHY CHOOSE ALTASCIENCES FOR FLEXIBLE LC-MS AND HYBRID LC/MS BIOANALYSIS

Altasciences provides high-precision, reproducible LC-MS/MS bioanalytical services to support every phase of drug development—from early discovery through clinical trials. Whether you need support for a single study or a complete development program, we adapt to your needs.

Our scientists work with your team to develop LC-MS/MS strategies tailored to your specific compounds, matrices, as well as therapeutic objectives and hybrid workflows to enhance sensitivity and selectivity.

Here’s what sets us apart:

  • Comprehensive Molecule Coverage: We accurately quantify small molecules, peptides, proteins, monoclonal antibodies, ADCs, and oligonucleotides using advanced LC-MS/MS techniques.
  • Advanced Hybrid Workflows: We boost selectivity and sensitivity by applying immunoaffinity enrichment and hybrid LC-MS workflows.
  • Microsampling Capabilities: We enable low-volume blood sampling to support both preclinical and clinical studies—minimizing animal stress, reducing patient burden, and improving study feasibility.
  • Customized Solutions: We deliver tailored strategies and specialized workflows to support biologics and novel therapeutic modalities.
  • Commitment to Quality and Compliance: We ensure regulatory-grade data integrity by enforcing rigorous quality controls and compliance-driven processes.
  • Streamlined Development Timelines:Our experienced team partners with you to design the most effective strategies for your unique project needs.
  • Collaborative Approach: We accelerate decision-making by streamlining processes and providing real-time data insights.
  • Integrated Preclinical and Clinical Solutions: We provide seamless support across all development phases—from standalone services to fully integrated program solutions.

Talk to one of our LC-MS experts today.

PARTNER WITH US TODAY

Partner with experts who bring extensive experience and a commitment to quality, navigating your studies with ease. Our tailored solutions, supported by our flexible bioanalytical services, lay a solid foundation for your drug development journey.

Send us a message to get started!

OUR COMPLETE RANGE OF BIOANALYTICAL SERVICES

Explore Altasciences' comprehensive bioanalytical services, designed to deliver accurate and reliable data at every drug development stage. From method development to sample analysis to immunogenicity testing, gene therapy support, biomarker analysis, and more, our expertise facilitates seamless integration with your preclinical and clinical programs, supporting confident decision-making.

Explore

Related Resources

View this fact sheet that summarizes our bioanalysis services, which includes both small and large molecules, from the discovery stage, to preclinical, all the way to Phase IV.


In this fact sheetfind out how our specialized expertise and advanced bioanalytical platforms support ADC development—from early PK/PD assessment to complex clinical studies.


Explorethis infographic to better understand the differences between LBA and LC-MS platforms—and gain clarity on which is best suited for your study or program.



In this eBook we discuss our seamless service offering for small molecule drug development from the discovery stage to Phase IV and beyond.

Check out this eBook which discusses the process of large molecule drug development, and how our full-scale service offering can help streamline the process.



Read Issue 30 of The Altascientist to explore the benefits of stable isotope labelled internal standards in LC-MS, along with recent advances in MS technology, bioanalysis, and more.



In Issue 16 of The Altascientist, discover how microsampling enhances preclinical, clinical, and bioanalytical research, featuring case studies on anti-epileptic drug monitoring and rituximab analysis.



ANSWERING YOUR KEY QUESTIONS ABOUT OUR LC-MS/MS OFFERING

Selecting the right LC-MS partner is critical for generating precise, reproducible data that drives confident drug development decisions.

Here are some answers to our most-asked questions:

Can you accurately quantify both small and large molecules?

  • Yes, we have extensive expertise in quantifying a wide range of molecules. Our LC-MS and hybrid LC-MS workflows are designed to deliver precise and sensitive measurements for both small and large molecule bioanalysis.

Do you offer customized LC-MS assay development and validation to meet specific program requirements?

  • Absolutely. We offer customized LC-MS assay development and validation services tailored to your specific program needs, ensuring regulatory compliance and high-quality data delivery.

What measures do you take to ensure data integrity, reproducibility, and regulatory compliance?

  • We follow strict quality control and regulatory guidelines, including for GLP and GCP compliance. Our bioanalytical processes incorporate rigorous method validation, controlled workflows, and comprehensive data audits to ensure accuracy, reproducibility, and regulatory readiness.

Do you provide microsampling capabilities for low-volume sample collection and analysis?

  • Yes, we have developed specialized workflows that integrate microsampling techniques, allowing for low-volume blood collection and sample analysis without compromising data quality.

How do you handle high-throughput workflows while maintaining assay robustness?

  • Our laboratories have automated sample preparation systems and streamlined LC-MS workflows, enabling high-throughput analysis while maintaining assay robustness, precision, and reproducibility.

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